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We have been covering the development of this phone dating back to last November. From time-to-time, some news leaks out about the still unannounced handset. Earlier this month, speculation about the Xplay 5S included its use of the Snapdragon SoC , which would point to a launch no earlier than late next quarter. Today, some fresh images of the Vivo Xplay 5S have appeared, with one picture giving us a clear look at the back of the unit. Based on the photo, the Xplay 5S will feature a laser auto focus for the rear camera, dual two-tone flash, and a fingerprint scanner that is nestled underneath the camera.

We also can see the volume rocker above the power button on the right side of the phone. Another picture shows the handset from the top down. There isn’t anything terribly exciting in this photo, unless a 3. The picture also shows off the metal border on the front of the device, and a secondary noise cancelling microphone.

The Vivo Xplay 5S is expected to carry a 6-inch display with 2. The latest rumor calls for a 21MP rear-facing snapper, and a 12MP shooter in front for selfies.

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Construction – Part 1 by: But a few months into the construction of the house, she had to return to the US for a couple of weeks for some urgent business, and she asked me to go to Cebu and watch over the construction. Fortunately, at that time I think I was about 23 or 24 then I was not very busy with my work and I also wanted to take a breather, so lipad ako papuntang Cebu. I found out that giniba pala totally yung lumang bahay ng Aunt ko, and at the back of their residential lot they constructed a 2-storey wooden-bamboo house where all their stuff were stored temporarily, and where my Aunt also stayed.

It faces the new house that’s being constructed, and malapit nang matapos. Ikakabit na lang yung windows and doors, but most of the structures were finished. Five days after I arrived, my Aunt left me na by myself to watch over the construction. While my Aunt was there, I was only able to meet the architect and foreman dahil sila nag-e-explain sa akin at sa Aunt ko ng mga ginagawa pa nila. But when she left, I decided I would try to interact with them more closely dahil yari ako pag may nangyaring hindi maganda sa construction, hehe, baka maging tabingi pa yung ibang bintana e mahirap dumungaw.

Latest images of the Vivo Xplay 5S surface

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But the remarkable stability of polyhedra can be applied on slow-release carriers of cytokines for tissue engineering. Here we show the complete healing in critical-sized bone defects by bone morphogenetic protein-2 BMP-2 encapsulated polyhedra. Although absorbable collagen sponge ACS safely and effectively delivers recombinant human BMP-2 rhBMP-2 into healing tissue, the current therapeutic regimens release rhBMP-2 at an initially high rate after which the rate declines rapidly.

ACS impregnated with BMP-2 polyhedra had enough osteogenic activity to promote complete healing in critical-sized bone defects, but ACS with a high dose of rhBMP-2 showed incomplete bone healing, indicating that polyhedral microcrystals containing BMP-2 promise to advance the state of the art of bone healing. Most secreted molecules including growth factors, chemokines and cytokines do not diffuse far but are bound to the cell surface or surrounding extracellular matrices ECM to regulate cell function in vivo.

The ECM functions as a reservoir for various kinds of soluble growth factors. Conversely, cells regulate degradation or remodeling of the ECM by secreting proteases and their inhibitors. Thus, the behavior of individual cells and tissue dynamics are regulated by intricate reciprocal interactions between cells and their surrounding micro-environment. Considering a dynamic complexity of the in vivo situation, there is an urgent need to develop new tools to reconstitute or modulate the extracellular micro-environment in vitro.

Research has shown that BMP-2 induces new bone formation in animal models. It is now well recognized to be one of the key osteogenic factors in the field of bone-tissue engineering 1 , 2 , 3 , and it has been approved for limited clinical use in the form of rhBMP-2 4. For the best healing, rhBMP-2 should be present in the healing tissue at a constant concentration. Although an external metering system that delivers the drug continuously into the healing tissue through a tube is theoretically possible, large practical hurdles stand in the way of implementing such a system.

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Formula 20 formula 22 Formula 25 formula 26 Formula 29 formula 30 Formula 36 formula 37 where the symbols and indices have the following meanings: Also preferred is a matrix material A; containing at least one compound of formula 38 or 39 Formula 38 Formula 39 wherein o is a number and where the symbols m, R 1 and R 3 defined under the formula 1 have the meanings given to 4.

Further preferred are inorganic phosphorus oxides and phosphorus sulfides such as P 4 O 10 degrees. Also preferred is a matrix material A, containing at least one 9,9′-Spirobifluoreneinheit. Also preferred is a matrix material A, containing at least one compound of formula 40 to 48 , Formula 40 formula 41 formula 42 Formula 43 formula 44 formula 45 Formula 46 Formula 47 Formula 48 wherein the symbols L, M, Z, R 1 and R 3 defined under the formulas 1 to said 37 meanings and applies to the other symbols and indices: Particularly preferred are mixtures which contain one or more of the above by formulas 1 matrix materials A through 48 , characterized in that they are chiral.

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These findings have been discovered based on the preparation of production cells for a protein comprising a truncated form of an extracellular region protein of Frizzled 2, and the characterization of mice to which the protein is administered. In particular, patients with femoral neck fractures and vertebral body fractures become bedridden, which causes significant deterioration of the quality of life thereof, and the social, medical, and economic burdens caused by care and hospital treatment have increased Non-Patent Literatures 1 and 2.

It has also been discovered in recent years that osteoporosis is significantly associated with mortality in old age Non Patent Literatures 3 and 4. Under such circumstances, prevention and treatment of osteoporosis have become critical objectives to be achieved. The former type is a pathological condition heretofore referred to as postmenopansal osteoporosis or senile osteoporosis.

According to the above classification, endocrine causes include such as hyperparathyreosis, hyperthyreosis, hypogonadism, Cushing’s syndrome, somatotropin deficiency, diabetes, Addison’s disease, and calcitonin deficiency.

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